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Drug—membrane interactions: Silymarin, silibyn and microsomal membranes
Author(s) -
Parasassi T.,
Martellucci A.,
Conti F.,
Messina B.
Publication year - 1984
Publication title -
cell biochemistry and function
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.933
H-Index - 61
eISSN - 1099-0844
pISSN - 0263-6484
DOI - 10.1002/cbf.290020206
Subject(s) - membrane , microsome , chemistry , drug , pharmacology , biochemistry , medicine , enzyme
Silymarin and silibyn are extracted from the seeds of Silybum marianum and used as a liver protectant because of their free radical scavenging. When incorporated into rabbit liver microsomes they cause a small decrease in the flourescence anisotropy of 1,6‐diphenyl‐1,3,5‐hexatrine (DPH) but not of 1‐anilinononaphthalene‐8‐sulphonic acid (ANS), incorporated into the membranes. They do, however, reduce the fluorescence intensity of incorporated ANS without changing the wavelength of maximum intensity. These observations suggest that the drugs are incorporated into the hydrophobic–hydrophilic interface of the microsomal bilayer and perturb the structure by influencing the packing of the acyl chains.