Premium
Hydrolysis of thyroglobulin inside isolated rat thyroid and liver lysosomes
Author(s) -
Fouchier Francis,
Dang Josseline,
Bastiani Paul,
Peyron Claude,
Mego John L.
Publication year - 1984
Publication title -
cell biochemistry and function
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.933
H-Index - 61
eISSN - 1099-0844
pISSN - 0263-6484
DOI - 10.1002/cbf.290020203
Subject(s) - thyroglobulin , in vivo , hydrolysis , thyroid , in vitro , chemistry , endocrinology , medicine , biochemistry , biology , microbiology and biotechnology
In vitro , poorly iodinated thyroglobulin (Tg) is hydrolysed at the same rate whether it is enclosed in thyroid or in liver lysosomes, while fully iodinated Tg is degraded faster inside liver lysosomes. After in vivo TSH administration, thyroid lysosomes hydrolyse fully iodinated Tg as fast as do liver lysosomes.