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Role of transferrin in uptake of non‐physiological metals into cells
Author(s) -
PlanasBohene Felicitas,
Taylor David M.,
Duffield John R.,
Darai Gholamreza
Publication year - 1983
Publication title -
cell biochemistry and function
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.933
H-Index - 61
eISSN - 1099-0844
pISSN - 0263-6484
DOI - 10.1002/cbf.290010303
Subject(s) - transferrin , chemistry , biochemistry , biophysics , microbiology and biotechnology , biology
At physiological concentrations of citrate the uptake of 59 Fe, 67 Ga, and 239 Pu into human type B lymphocytes of splenic origin is the same in viable and in non‐viable cells. Addition of transferrin has no effect on the uptake into non‐viable cells but in viable cells it increases the uptake of Fe and Ga but decreases that of Pu. Uptake decreases as transferrin concentration increases although this is less marked with Ga.