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Lysosomal membrane recovery following labilization by thyroid stimulators
Author(s) -
Neylan D.,
Smyth P. P. A.
Publication year - 1983
Publication title -
cell biochemistry and function
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.933
H-Index - 61
eISSN - 1099-0844
pISSN - 0263-6484
DOI - 10.1002/cbf.290010213
Subject(s) - thyroid , membrane , stimulation , guinea pig , endocrinology , medicine , chemistry , membrane permeability , follicular phase , enzyme , biochemistry
Lysosomal membrane permeability was assessed by measuring freely available napthylamidase activity in intact preparations of guinea pig thyroid follicular cells following exposure of thyroid tissue to sequential stimulation by two thyroid stimulators, thyrotrophin (TSH) and thyroid stimulating immunoglobulins (TSI). These investigations showed that following labilization by TSH, the lysosomal membranes recovered and were capable of responding to a second thyroid stimulator (TSI). That such recovery represented restabilization of lysosomal membranes was confirmed by the finding that latent naphthylamidase activity was restored without a change in total activity of the enzyme.