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Dispersed sensory ganglion cells cleave an active entity from nerve growth factor coupled to Sepharose
Author(s) -
Khan A. A.,
Pearce F. L.,
Ver C. A.
Publication year - 1983
Publication title -
cell biochemistry and function
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.933
H-Index - 61
eISSN - 1099-0844
pISSN - 0263-6484
DOI - 10.1002/cbf.290010207
Subject(s) - cleave , nerve growth factor , ganglion , sepharose , sensory system , embryonic stem cell , microbiology and biotechnology , chemistry , sensory neuron , receptor , biology , biochemistry , neuroscience , enzyme , gene
Dispersed sensory ganglion cells from the embryonic chick, but not cells from other tissues, liberate biologically active material from nerve growth factor coupled to Sepharose beads. Experiments with such insolubilized material cannot then be taken as evidence for the existence of an external membrane receptor for the factor and may indicate that responsive cells have the ability to cleave an active fragment from the polypeptide.