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Physical training prevents oxidative stress in L‐NAME‐induced hypertension rats
Author(s) -
Cardoso Andréia Machado,
Martins Caroline Curry,
Fiorin Fernando da Silva,
Schmatz Roberta,
Abdalla Fátima Husein,
Gutierres Jessié,
Zanini Daniela,
Fiorenza Amanda Maino,
Stefanello Naiara,
Serres Jonas Daci da Silva,
Carvalho Fabiano,
Castro Verônica Paiva,
Mazzanti Cinthia Melazzo,
Royes Luiz Fernando Freire,
BellóKlein Adriane,
Goularte Jeferson Ferraz,
Morsch Vera Maria,
Bagatini Margarete Dulce,
Schetinger Maria Rosa Chitolina
Publication year - 2013
Publication title -
cell biochemistry and function
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.933
H-Index - 61
eISSN - 1099-0844
pISSN - 0263-6484
DOI - 10.1002/cbf.2868
Subject(s) - npsh , medicine , endocrinology , oxidative stress , superoxide dismutase , chemistry , nitric oxide , antioxidant , creatinine , urea , catalase , physical exercise , enzyme , biochemistry , glutathione
The present study investigated the effects of a 6‐week swimming training on blood pressure, nitric oxide (NO) levels and oxidative stress parameters such as protein and lipid oxidation, antioxidant enzyme activity and endogenous non‐enzymatic antioxidant content in kidney and circulating fluids, as well as on serum biochemical parameters (cholesterol, triglycerides, urea and creatinine) from Nω‐nitro‐L‐arginine methyl ester hydrochloride (L‐NAME)‐induced hypertension treated rats. Animals were divided into four groups ( n = 10): Control, Exercise, L‐NAME and Exercise L‐NAME. Results showed that exercise prevented a decrease in NO levels in hypertensive rats ( P < 0·05). An increase in protein and lipid oxidation observed in the L‐NAME‐treated group was reverted by physical training in serum from the Exercise L‐NAME group ( P < 0·05). A decrease in the catalase (CAT) and superoxide dismutase (SOD) activities in the L‐NAME group was observed when compared with normotensive groups ( P < 0·05). In kidney, exercise significantly augmented the CAT and SOD activities in the Exercise L‐NAME group when compared with the L‐NAME group ( P < 0·05). There was a decrease in the non‐protein thiols (NPSH) levels in the L‐NAME‐treated group when compared with the normotensive groups ( P < 0·05). In the Exercise L‐NAME group, there was an increase in NPSH levels when compared with the L‐NAME group ( P < 0·05). The elevation in serum cholesterol, triglycerides, urea and creatinine levels observed in the L‐NAME group were reverted to levels close to normal by exercise in the Exercise L‐NAME group ( P < 0·05). Exercise training had hypotensive effect, reducing blood pressure in the Exercise L‐NAME group ( P < 0·05). These findings suggest that physical training could have a protector effect against oxidative damage and renal injury caused by hypertension. Copyright © 2012 John Wiley & Sons, Ltd.