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Prostate cancer is known by the companionship with ATM and miRNA it keeps: craftsmen of translation have dual behaviour with tailors of life thread
Author(s) -
Farooqi Ammad Ahmad,
Naqi Ali,
Qureshi Muhammad Zahid,
Rana Aamir,
Khan Ammara,
Riaz Asma M.,
Afzal Syed Muhammad Faheem,
Rasheed Nabeelah,
Bhatti Shahzad
Publication year - 2012
Publication title -
cell biochemistry and function
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.933
H-Index - 61
eISSN - 1099-0844
pISSN - 0263-6484
DOI - 10.1002/cbf.2847
Subject(s) - carcinogenesis , microrna , prostate cancer , biology , dual (grammatical number) , dual role , computational biology , cognitive science , psychology , cancer , genetics , gene , philosophy , chemistry , combinatorial chemistry , linguistics
Research on prostate cancer progression has focused extensively on the concept of miRNA, which can operate either as promoters or as suppressors of carcinogenesis. Moreover, recent genetic studies and emerging functional work show that strikingly similar and overlapping pathways are involved in prostate carcinogenesis. Unswervingly, these elements constitute a recently explored ‘network of networks’ that dynamically reorganizes during DNA damage and is responsible for positively or negatively regulating genome organization and integrity. We consider these facets of convergence and discuss how insights from diametrically opposed interactions of ataxia–telangiectasia mutated and mitrons can inform us about, and possibly help us to get a step closer to personalized medicine. Copyright © 2012 John Wiley & Sons, Ltd.