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Acute administration of the organochalcogen 3‐methyl‐1‐phenyl‐2‐(phenylseleno)oct‐2‐en‐1‐one induces biochemical and hematological disorders in male rats
Author(s) -
Santos Lacerda Denise,
Oliveira Castro Vanessa,
Mascarenhas Marcello,
Guerra Robson Brum,
Dani Caroline,
Coitinho Adriana,
Gomez Rosane,
Funchal Cláudia
Publication year - 2012
Publication title -
cell biochemistry and function
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.933
H-Index - 61
eISSN - 1099-0844
pISSN - 0263-6484
DOI - 10.1002/cbf.2806
Subject(s) - creatinine , hemoglobin , hematocrit , lactate dehydrogenase , medicine , acute toxicity , toxicity , endocrinology , urea , white blood cell , lymphocyte , alanine aminotransferase , blood urea nitrogen , chemistry , biochemistry , enzyme
Organochalcogens are extensively produced and employed by industry and agriculture, and the risk of occupational and environmental toxicity to them has been poorly understood. Here, we investigated the acute effect of a new organochalcogen 3‐methyl‐1‐phenyl‐2‐(phenylseleno)oct‐2‐en‐1‐one on biochemical and hematological parameters in male Wistar rats. The animals were treated with a single intraperitoneal injection of the organochalcogen at doses of 125, 250 or 500 µg·kg –1 . After 60 min, the animals were sacrificed by decapitation, and the trunk blood was collected for determination of glucose, triglycerides, cholesterol, alanine aminotransferase (ALT), aspartate aminotransferase, lactate dehydrogenase, urea, creatinine, C‐reactive protein, red blood cells, hematocrit, hemoglobin and white blood cells (WBC). Our results showed a reduction in cholesterol levels in all treated groups, an increase in ALT activity at doses of 250 and 500 µg·kg –1 , a decrease of hemoglobin and an increase in WBC in animals that received 250 and 500 µg·kg –1 of the organoselenium. In addition, we observed an increase in neutrophil counts at 125 µg·kg –1 dose and a decrease at 500 µg·kg –1 dose. We also verified an increase in lymphocyte counts at the dose of 500 µg·kg –1 . Thus, the present study shows that the acute treatment with this new organochalcogen causes biochemical changes and hematological disorders in male rats. Copyright © 2012 John Wiley & Sons, Ltd.