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Triptolide inhibits colon cancer cell proliferation and induces cleavage and translocation of 14‐3‐3 epsilon
Author(s) -
Liu Yawei,
Song Fangli,
Wu William K. K.,
He Minyi,
Zhao Liang,
Sun Xuegang,
Li Hui,
Jiang Yong,
Yang Yungao,
Peng Kang
Publication year - 2012
Publication title -
cell biochemistry and function
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.933
H-Index - 61
eISSN - 1099-0844
pISSN - 0263-6484
DOI - 10.1002/cbf.2793
Subject(s) - triptolide , tripterygium wilfordii , apoptosis , chromosomal translocation , cleavage (geology) , colorectal cancer , in vitro , in vivo , cancer cell , chemistry , cancer research , cell growth , cell , tripterygium , cancer , pharmacology , biochemistry , biology , medicine , stereochemistry , pathology , genetics , paleontology , alternative medicine , fracture (geology) , glycoside , gene
Triptolide is a diterpenoid triepoxide derived from the traditional Chinese medical herb Tripterygium wilfordii . In the present study, we demonstrated that this phytochemical attenuated colon cancer growth in vitro and in vivo . Using a proteomic approach, we found that 14‐3‐3 epsilon, a cell cycle‐ and apoptosis‐related protein, was altered in colon cancer cells treated with triptolide. In this regard, triptolide induced cleavage and perinuclear translocation of 14‐3‐3 epsilon. Taken together, our findings suggest that triptolide may merit investigation as a potential therapeutic agent for colon cancer, and its anticancer action may be associated with alteration of 14‐3‐3 epsilon. Copyright © 2012 John Wiley & Sons, Ltd.