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The effect of curcumin in the ectonucleotidases and acetylcholinesterase activities in synaptosomes from the cerebral cortex of cigarette smoke‐exposed rats
Author(s) -
Jaques Jeandre Augusto dos Santos,
Rezer João Felipe Peres,
Gonçalves Jamile Fabbrin,
Spanevello Rosélia Maria,
Gutierres Jessié Martins,
Pimentel Victor Câmera,
Thomé Gustavo Roberto,
Morsch Vera Maria,
Schetinger Maria Rosa Chitolina,
Leal Daniela Bitencourt Rosa
Publication year - 2011
Publication title -
cell biochemistry and function
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.933
H-Index - 61
eISSN - 1099-0844
pISSN - 0263-6484
DOI - 10.1002/cbf.1804
Subject(s) - curcumin , acetylcholinesterase , aché , chemistry , pharmacology , neuroprotection , smoke , acetylcholine , cigarette smoke , cerebral cortex , biochemistry , enzyme , medicine , toxicology , biology , organic chemistry
With the evidence that curcumin may be a potent neuroprotective agent and that cigarette smoke is associated with a decline in the cognitive performance as our bases, we investigated the activities of Ecto‐Nucleoside Triphosphate Diphosphohydrolase (NTPDase), 5'‐nucleotidase and acetylcholinesterase (AChE) in cerebral cortex synaptosomes from cigarette smoke‐exposed rats treated with curcumin (Cur). The experimental procedures entailed two sets of experiments. In the first set, the groups were vehicle, Cur 12·5, 25 and 50 mg·kg –1 ; those in the second set were vehicle, smoke, smoke and Cur 12·5, 25 and 50 mg·kg –1 . Curcumin prevented the increased NTPDase, 5'‐nucleotidase and AChE activities caused by smoke exposure. We suggest that treatment with Cur was protective because the decrease of ATP and acetylcholine (ACh) concentrations is responsible for cognitive impairment, and both ATP and ACh have key roles in neurotransmission. Copyright © 2011 John Wiley & Sons, Ltd.