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Acheron regulates vascular endothelial proliferation and angiogenesis together with Id1 during wound healing
Author(s) -
Sun Rongju,
Chen Wei,
Zhao Xiaodong,
Li Tanshi,
Song Qing
Publication year - 2011
Publication title -
cell biochemistry and function
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.933
H-Index - 61
eISSN - 1099-0844
pISSN - 0263-6484
DOI - 10.1002/cbf.1799
Subject(s) - angiogenesis , wound healing , vascular endothelial growth factor , mediator , integrin , endothelial stem cell , microbiology and biotechnology , extracellular matrix , cancer research , umbilical vein , human umbilical vein endothelial cell , immunology , medicine , biology , vegf receptors , receptor , in vitro , biochemistry
RNA binding protein acheron has proved to be either the mediator of integrin‐extracellular matrix interactions or the regulatory factor that participates in vertebrate development, cell differentiation and cell death. We report the role of acheron in vascular endothelial proliferation, angiogenesis and wound healing post‐trauma. Co‐immunoprecipitation showed that Acheron forms a ternary complex with β 1 integrin and Id1 in human umbilical vein endothelial cells following stimulation with serious trauma serum. Acheron, vascular endothelial growth factor (VEGF), and β 1 integrin mRNA expression was apparently inhibited, and capillary density and wound healing rate also were reduced in Id1‐deficient mice trauma model. Acheron together with Id1 significantly induces VEGF, not CD105 level inhibition by serious trauma serum for 24 h. In conclusion, we have demonstrated that acheron may be an effective mediator of promoting endothelial proliferation, angiogenesis and wound healing probably by regulating VEGF together with Id1. Copyright © 2011 John Wiley & Sons, Ltd.