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S100B promotes the proliferation, migration and invasion of specific brain metastatic lung adenocarcinoma cell line
Author(s) -
Jiang Weifeng,
Jia Qianxin,
Liu Lili,
Zhao Xinwen,
Tan Aixing,
Ma Ningqiang,
Zhang Helong
Publication year - 2011
Publication title -
cell biochemistry and function
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.933
H-Index - 61
eISSN - 1099-0844
pISSN - 0263-6484
DOI - 10.1002/cbf.1791
Subject(s) - brain metastasis , cancer research , apoptosis , metastasis , adenocarcinoma , cell growth , cell , cell culture , cell cycle , cell migration , biology , lung cancer , transfection , pathology , medicine , cancer , biochemistry , genetics
Brain metastasis frequently occurs in cancer patients and is associated with a poor prognosis. We previously reported that S100B was highly expressed in PC14/B, a specific brain metastatic lung adenocarcinoma cell line, which suggests that it is associated with brain metastasis of lung cancer. However, the role of S100B in brain metastasis remains to be elucidated. In this study, using PC14/B cell line, we found that siRNA mediated depletion of S100B in PC14/B cells led to notable differences in cell proliferation, apoptosis, cell cycle progression, colony formation ability, cell migratory and invasive activity compared with the mock‐transfected cells. Therefore, our data suggest that S100B promotes the brain metastasis of lung adenocarcinoma by promoting cell proliferation, preventing apoptosis and increasing cell migration and invasion. Copyright © 2011 John Wiley & Sons, Ltd.