Premium
Microparticles in physiological and in pathological conditions
Author(s) -
Roos Maria Augusta,
Gennero Luisa,
Denysenko Tetyana,
Reguzzi Stefano,
Cavallo Giovanni,
Pescarmona Gian Piero,
Ponzetto Antonio
Publication year - 2010
Publication title -
cell biochemistry and function
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.933
H-Index - 61
eISSN - 1099-0844
pISSN - 0263-6484
DOI - 10.1002/cbf.1695
Subject(s) - medicine , rheumatoid arthritis , pathological , angiogenesis , intensive care medicine , cancer , vaccination , stroke (engine) , immunology , pathology , mechanical engineering , engineering
Chronic diseases pose a severe burden to modern National Health Systems. Individuals nowadays have a far more extended lifespan than in the past, but healthy living was only scantily extended. As much as longer life is desirable, it is saddened by chronic diseases and organ malfunctions. One contributor to these problems was recognized to be represented by microparticles (MPs). Our purpose is to better understand MPs, to contrast their ominous threat and possible clinical importance. For this intent we correlated MPs with thrombotic pathologies, hemophilia, malaria, diabetes, cardiovascular diseases, endothelial dysfunctions, pulmonary hypertension, ischemic stroke, pre‐eclampsia, rheumatologic diseases—rheumatoid arthritis, polymyositis—dermatomyositis, angiogenesis and tumor progression—cancer; we listed the possibilities of using them to improve transfusion methods, as a marker for acute allograft rejection, in stem cell transplantation, as neuronal biomarkers, to understand gender‐specific susceptibility for diseases and to improve vaccination methods and we presented some methods for the detection of MPs. Copyright © 2010 John Wiley & Sons, Ltd.