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Prevalence of the fibrinogen β‐chain, angiotensin‐converting enzyme and plasminogen activator inhibitor‐1 polymorphisms in Costa Rican young adults with thrombotic disease
Author(s) -
Hidalgo Andrea,
SalazarSanchez Lizbeth,
Cartin Mayra,
Mendez Max,
Arauz Jorge,
Parajeles Alexander
Publication year - 2010
Publication title -
cell biochemistry and function
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.933
H-Index - 61
eISSN - 1099-0844
pISSN - 0263-6484
DOI - 10.1002/cbf.1655
Subject(s) - plasminogen activator inhibitor 1 , medicine , angiotensin converting enzyme , gastroenterology , fibrinogen , thrombosis , allele , plasminogen activator , endocrinology , gene polymorphism , venous thrombosis , genetics , biology , gene , blood pressure
Thrombotic disease is a multifactorial condition that involves both classical and genetic risk factors. We studied the association between the classical risk factors of hypertension and smoking, and polymorphisms on the genes of the angiotensin‐converting enzyme (ACE), the β‐chain of fibrinogen (FG), and the plasminogen activator inhibitor‐1 (PAI‐1) in patients with venous and arterial thrombosis. The present investigation is a retrospective case–control study. A total of 340 participants were analyzed, including 162 patients and 178 healthy controls. Hypertension and smoking showed a significant association with thrombotic disease ( p < 0.05) but FG level was found significant risk factor only for the venous thrombosis (VT) group ( p < 0.04). Significant differences between thrombotic groups were found for the studied polymorphisms of PAI‐1 ( p < 0.0014), but for both FG β ‐chain gene polymorphisms, none of the molecular analyses showed a positive sample for any mutating allele ( p > 0.05). For the ACE polymorphism, the I allele present a protective effect in the general thrombotic group. This is one of the first reports in a Latin‐American population dealing with these molecular markers and thrombotic diseases. Copyright © 2010 John Wiley & Sons, Ltd.