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Growth factors and glucose homeostasis in diabetic rats: effects of exercise training
Author(s) -
Gomes Ricardo José,
Leme José Alexandre Curiacos de Almeida,
de Moura Leandro Pereira,
de Araújo Michel Barbosa,
Rogatto Gustavo Puggina,
de Moura Rodrigo Ferreira,
Luciano Eliete,
de Mello Maria Alice Rostom
Publication year - 2009
Publication title -
cell biochemistry and function
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.933
H-Index - 61
eISSN - 1099-0844
pISSN - 0263-6484
DOI - 10.1002/cbf.1556
Subject(s) - medicine , endocrinology , glucose homeostasis , glycogen , homeostasis , diabetes mellitus , insulin , insulin like growth factor , alloxan , hormone , insulin resistance , growth factor , receptor
To investigate the alterations of glucose homeostasis and variables of the insulin‐like growth factor‐1 (IGF‐1) growth system in sedentary and trained diabetic (TD) rats, Wistar rats were divided into sedentary control (SC), trained control (TC), sedentary diabetic (SD), and TD groups. Diabetes was induced by Alloxan (35 mg kg −1 b.w.). Training program consisted of swimming 5 days week −1 , 1 h day −1 , during 8 weeks. Rats were sacrificed and blood was collected for determinations of serum glucose, insulin, growth hormone (GH), IGF‐1, and IGF binding protein‐3 (IGFBP‐3). Muscle and liver were removed to evaluate glycogen content. Cerebellum was extracted to determinate IGF‐1 content. Diabetes decreased serum GH, IGF‐1, IGFBP‐3, liver glycogen, and cerebellum IGF‐1 peptide content in baseline condition. Physical training recovered liver glycogen and increased serum and cerebellum IGF‐1 peptide in diabetic rats. Physical training induces important metabolic and hormonal alterations that are associated with an improvement in glucose homeostasis and serum and cerebellum IGF‐1 concentrations. Copyright © 2009 John Wiley & Sons, Ltd.