Staurosporine induces tyrosine phosphorylation in  Dictyostelium discoideum  proteins | Zendy

Andrioli Luiz Paulo | Zendy; Souza Glaucia Mendes | Zendy; da Silva Aline Maria | Zendy

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Staurosporine induces tyrosine phosphorylation in Dictyostelium discoideum proteins

Author(s) -

Andrioli Luiz Paulo,

Souza Glaucia Mendes,

da Silva Aline Maria

Publication year - 2006

Publication title -

cell biochemistry and function

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.933

H-Index - 61

eISSN - 1099-0844

pISSN - 0263-6484

DOI - 10.1002/cbf.1368

Subject(s) - dictyostelium discoideum , staurosporine , phosphorylation , microbiology and biotechnology , tyrosine phosphorylation , dictyostelium , tyrosine kinase , biology , kinase , tyrosine , cell , biochemistry , protein kinase a , signal transduction , gene

The treatment of cells with staurosporine results in inhibition and less frequently activation of protein kinases, in a cell‐type specific manner. In the social amoeba Dictyostelium discoideum , staurosporine induces marked changes in cell morphology affecting growth and development. Here we describe that incubation of D. discoideum growing or starved cells with staurosporine results in a rapid and unexpected tyrosine phosphorylation on two polypeptides of ∼64 and ∼62 kDa. These proteins emerge as novel substrates for tyrosine phosphorylation opening up new perspectives for the study of cell signalling in D. discoideum. Copyright © 2006 John Wiley & Sons, Ltd.

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