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Hypolipidemic effect and antioxidant activity of glycoprotein isolated from Ulmus davidiana Nakai in Triton WR‐1339‐treated mouse
Author(s) -
Ko JeongHyeon,
Lee SeiJung,
Lim KyeTaek
Publication year - 2006
Publication title -
cell biochemistry and function
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.933
H-Index - 61
eISSN - 1099-0844
pISSN - 0263-6484
DOI - 10.1002/cbf.1337
Subject(s) - antioxidant , chemistry , tbars , catalase , thiobarbituric acid , glycoprotein , superoxide dismutase , biochemistry , probucol , lipid peroxidation
The glycoprotein isolated from Ulmus davidiana Nakai (UDN) (UDN glycoprotein) has a molecular weight of 116 kDa and consists of 78.65% carbohydrate content and 21.35% protein content. In the present study, we investigated the hypolipidemic effect of UDN glycoprotein on Triton WR‐1339‐induced mice. With pretreatment with UDN glycoprotein, the triacylglycerol (TAG), total cholesterol and low density lipoprotein‐cholesterol (LDL‐C) concentrations were significantly reduced, whereas high density lipoprotein‐cholesterol (HDL‐C) concentration was increased in the plasma of Triton WR‐1339‐induced mice. With respect to antioxidative activity, UDN glycoprotein significantly decreased the level of thiobarbituric acid reactive substances (TBARS) and improved activities of catalase and glutathione peroxidase (GPx), without an apparent change of superoxide dismutase (SOD) activity. Also UDN glycoprotein significantly increased nitric oxide (NO) production in Triton WR‐1339‐induced mice. These results indicate that UDN glycoprotein has a hypolipidemic effect, possesses antioxidant activity and has an ability to stimulate NO production. Thus, we speculate that UDN glycoprotein is an example of natural compound that lowers plasma lipid level together with having an antioxidant function in Triton WR‐1339‐induced mice. Copyright © 2006 John Wiley & Sons, Ltd.