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A microscopic study of kidney tissue in familial mediterranean fever patients
Author(s) -
Sarı Kılıçaslan Seda M.,
Ayvalı Cevat,
Taştan Hakkı
Publication year - 2005
Publication title -
cell biochemistry and function
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.933
H-Index - 61
eISSN - 1099-0844
pISSN - 0263-6484
DOI - 10.1002/cbf.1286
Subject(s) - pathology , vacuolization , familial mediterranean fever , nephrotic syndrome , kidney , ultrastructure , medicine , disease , kidney disease , lumen (anatomy) , glomerular basement membrane , chemistry , anatomy , proteinuria
Familial Mediterranean Fever (FMF) is an autosomal recessive hereditary disease leading mostly to renal failure and nephrotic syndrome. The ultrastructure of kidney has not been fully investigated in FMF associated renal disease. The aim of this study is to provide further evidence on the ultrastructure of kidney in patients with FMF who suffer from renal disease. Renal biopsies obtained from two patients who were diagnosed with FMF renal disease complications were examined. Examination of renal tissue by light and electron microscopy identified degenerations both in tubules and the filtration barrier. Foot processes were partly effaced. Amorphous material was found in thickened glomerular basement membranes. Fibrous material deposits in thick Bowman's capsule wall were also seen. Finally, degeneration in the form of folding of plasma membrane and vacuolization as well as fusion in mitochondria cristae, was observed. Accumulation of tissue remnants in the lumen was also found in tubules. Copyright © 2005 John Wiley & Sons, Ltd.