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Effect of polyunsaturated fatty acid‐enriched phosphatidylcholine and phosphatidylserine on butyrate‐induced growth inhibition, differentiation and apoptosis in Caco‐2 cells
Author(s) -
Hossain Zakir,
Konishi Megumi,
Hosokawa Masashi,
Takahashi Koretaro
Publication year - 2006
Publication title -
cell biochemistry and function
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.933
H-Index - 61
eISSN - 1099-0844
pISSN - 0263-6484
DOI - 10.1002/cbf.1202
Subject(s) - sodium butyrate , phosphatidylserine , phosphatidylcholine , butyrate , apoptosis , polyunsaturated fatty acid , caco 2 , alkaline phosphatase , chemistry , biochemistry , growth inhibition , cell growth , cell , fatty acid , enzyme , phospholipid , membrane , fermentation , gene
Abstract Phospholipids are fascinating in terms of important bio‐functional compounds. The present work investigated the effect of polyunsaturated phosphatidylcholine (PC) and phosphatidylserine (PS) on butyrate‐induced growth inhibition, differentiation and apoptosis using Caco‐2 cells. Growth inhibition of Caco‐2 cells became apparent 24 h after addition of PC while it took 48 h with PS. Alkaline phosphatase activity of Caco‐2 cells increased with combined PC or PS and sodium butyrate (NaBT) at 72 h, indicating that PC and PS enhanced cell differentiation in the presence of NaBT. An increased enrichment factor was also found when cells were treated with combinations of PC or PS and NaBT. These results suggest that marine PC and PS can be considered to be potentially useful colon cancer chemotherapy agents with high bio‐availability. Copyright © 2005 John Wiley & Sons, Ltd.