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Glutamine‐dependent changes in gene expression and protein activity
Author(s) -
Curi R.,
Lagranha C. J.,
Doi S. Q.,
Sellitti D. F.,
Procopio J.,
PithonCuri T. C.
Publication year - 2004
Publication title -
cell biochemistry and function
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.933
H-Index - 61
eISSN - 1099-0844
pISSN - 0263-6484
DOI - 10.1002/cbf.1165
Subject(s) - glutamine , biochemistry , amino acid , protein biosynthesis , gene expression , biology , chemistry , microbiology and biotechnology , gene
The functions of glutamine are many and include, substrate for protein synthesis, anabolic precursor for muscle growth, acid–base balance in the kidney, substrate for ureogenesis in the liver, substrate for hepatic and renal gluconeogenesis, an oxidative fuel for intestine and cells of the immune system, inter‐organ nitrogen transport, precursor for neurotransmitter synthesis, precursor for nucleotide and nucleic acid synthesis and precursor for glutathione production. In the present review information on the mechanism of glutamine action is presented. This amino acid has been shown to regulate the expression of several genes (such as p47 phox , p22 phox , gp91 phox , α‐actin and fibronectin) and activate several proteins (such as ASK1, c‐myc, c‐jun and p70 s6k ). Copyright © 2004 John Wiley & Sons, Ltd.