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Plasma xanthine oxidase, superoxide dismutase and glutathione peroxidase activities and uric acid levels in severe and mild pre‐eclampsia
Author(s) -
Yildirim Abdulkadir,
Altinkaynak Konca,
Aksoy Hulya,
Sahin Y. Nuri,
Akcay Fatih
Publication year - 2004
Publication title -
cell biochemistry and function
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.933
H-Index - 61
eISSN - 1099-0844
pISSN - 0263-6484
DOI - 10.1002/cbf.1090
Subject(s) - xanthine oxidase , glutathione peroxidase , superoxide dismutase , uric acid , chemistry , eclampsia , medicine , superoxide , peroxidase , glutathione , antioxidant , endocrinology , biochemistry , enzyme , pregnancy , biology , genetics
The aim of the present study was to measure plasma uric acid (UA) levels and superoxide dismutase (SOD), glutathione peroxidase (GSH‐Px) and xanthine oxidase (XO) activities and to evaluate the relationship between these parameters and the severity of pre‐eclampsia. Twenty‐five pre‐eclamptic, 15 healthy pregnant and 15 non‐pregnant women were enrolled in this study. Increased mean plasma XO activity was found to be higher in both pre‐eclampsia groups than in the healthy pregnant group. Plasma UA levels were the highest in the severe pre‐eclampsia group among the study groups. SOD and GSH‐Px activities were significantly lower in both pre‐eclampsia groups than in the healthy pregnant group ( p < 0.005 and p < 0.001, respectively). Increased XO and decreased SOD and GSH‐Px activities may contribute to the pathophysiological mechanisms of pre‐eclampsia and increased UA may serve a protective role responding to superoxide radicals arising from increased XO activity or other sources in pre‐eclampsia. Copyright © 2004 John Wiley & Sons, Ltd.