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Antioxidant status and lipid peroxidation in type II diabetes mellitus
Author(s) -
Memısoğullari Ramazan,
Taysı Seyithan,
Bakan Ebubekir,
Capoglu Ilyas
Publication year - 2003
Publication title -
cell biochemistry and function
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.933
H-Index - 61
eISSN - 1099-0844
pISSN - 0263-6484
DOI - 10.1002/cbf.1025
Subject(s) - medicine , lipid peroxidation , ceruloplasmin , glutathione peroxidase , endocrinology , superoxide dismutase , diabetes mellitus , antioxidant , catalase , glutathione , type 2 diabetes mellitus , chemistry , oxidative stress , biochemistry , enzyme
Diabetes Mellitus (DM), a state of chronic hyperglycaemia, is a common disease affecting over 124 million individuals worldwide. In this study, erythrocyte glutathione levels, lipid peroxidation, superoxide dismutase, catalase, and glutathione peroxidase and some extracellular antioxidant protein levels of patients with type II diabetes mellitus and healthy controls were investigated. Thirty‐eight patients (21 males; with age of mean ± SD, 53.1 ± 9.7 years) and 18 clinically healthy subjects (10 males; with age of mean ± SD, 49.3 ± 15.2 years) were included in the study. Levels of erythrocyte lipid peroxidation, serum ceruloplasmin and glucose levels, HbA 1C levels, and erythrocyte catalase activity were significantly increased, whereas serum albumin and transferrin levels, erythrocyte glutathione levels, and glutathione peroxidase activity were significantly decreased compared to those of controls. There was no significant difference in superoxide dismutase activity compared to controls. The results suggest that the antioxidant deficiency and excessive peroxide‐mediated damage may appear in non‐insulin dependent diabetes mellitus. Copyright © 2003 John Wiley & Sons, Ltd.