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A Decavandate Sandwiched by Diprotonated Cryptands‐222: Model for the Vanadate‐Ionophore Interaction
Author(s) -
Farahbakhsh Mahin,
Schmidt Häke,
Rehder Dieter
Publication year - 1997
Publication title -
chemische berichte
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 0009-2940
DOI - 10.1002/cber.19971300814
Subject(s) - cryptand , chemistry , protonation , ionophore , vanadate , molecule , vanadium , crystallography , medicinal chemistry , inorganic chemistry , stereochemistry , ion , organic chemistry , calcium
Treatment of a C222‐vanadyl‐AMP complex (C222 = cryptand‐222, AMP = adenosine monophosphate) with Me 2 NH in the presence of air yielded centrosymmetric dihydrogen‐decavanadate H 2 V 10 O 4 28 , sandwiched by two diprotonated C222 molecules. An X‐ray crystal‐structure analysis was performed of this compound with the overall composition [C222(H + ) 2 ] 2 [H 2 V 10 O 28 ] · 2 1/2, H 2 O. Protonation sites in the anion are μ2‐oxygen atoms linking two different vanadium centres. Protonation sites at the cryptand are the nitrogen and/or oxygen atoms of one of the −[CH 2 ] 2 O[−CH 2 | 2 O|CH 2 ]– bridges. The relevance of the compound for the stabilisation and transport of the kinase and phosphatase inhibitor decavanadate by biogenic ionophores is addressed.