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New β‐Amino Alcohols as Chiral Ligands for the Catalytic Enantioselective Reduction of Prochiral Ketones and the Nucleophilic Addition of Diethylzinc to Benzaldehyde
Author(s) -
Peper Viola,
Martens Jürgen
Publication year - 1996
Publication title -
chemische berichte
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 0009-2940
DOI - 10.1002/cber.19961290616
Subject(s) - diethylzinc , chemistry , benzaldehyde , enantioselective synthesis , alkyl , catalysis , nucleophile , organic chemistry , nucleophilic addition , carbon atom , medicinal chemistry
New optically active β‐amino alcohols, derived from various acyclic and cyclic amino acids with alkyl groups on the carbinol carbon atom, were used in the enantioselective reduction of prochiral ketones. The attachment of alkyl groups to the nitrogen atom of the catalyst ( R )‐ 1b was shown to influence favorably the enantioselectivity of the addition of diethylzinc to benzaldehyde. In both cases the resulting secondary alcohols were obtained in moderate to high optical yields.