Zinc Complexes of Drugs Containing Nitrogen Heterocycles

Four drugs whose actions have a relation to the status of zinccontaining species in the human body were used as ligands in zinc complexes. Captopril (H 2 Cap) forms the compound [ZnCap] ( 1 ) presumed to be a coordination polymer with O and S coordination. Isoniazid, in the presence of zinc salts, is converted to 1,2‐diisonicotinoyl hydrazide (H 2 Nih) which forms polymeric [Zn(Nih)NH 3 ] ( 2 ) with trigonal‐bipyramidal ZnO 2 N 3 coordination. Nalidixic acid (HNal) and zinc perchlorate yield [Zn(HNal) 2 (H 2 O) 2 ](ClO 4 ) 2 · 2 H 2 O ( 3 ) containing zinc in an octahedral ZnO 6 environment. Mercaptopurine (H 2 Mer), in the presence of ammonia, forms [Zn(Mer)(NH 3 ) 2 ] . H 2 O ( 4 ) which is a coordination polymer containing tetrahedral ZnN 4 units. The structures of [Zn(Nih)NH 3 ], [Zn(HNal) 2 (H 2 O) 2 ](ClO 4 ) 2 . 2 H 2 O, and [Zn(Mer)(NH 3 ) 2 ] . 2 H 2 O were determined diffractometrically.