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Zinc Complexes of Drugs Containing Nitrogen Heterocycles
Author(s) -
Koppenhöfer Alrik,
Hartmann Uwe,
Vahrenkamp Heinrich
Publication year - 1995
Publication title -
chemische berichte
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 0009-2940
DOI - 10.1002/cber.19951280807
Subject(s) - chemistry , zinc , hydrazide , perchlorate , octahedron , trigonal bipyramidal molecular geometry , coordination complex , medicinal chemistry , stereochemistry , crystal structure , inorganic chemistry , crystallography , organic chemistry , metal , ion
Four drugs whose actions have a relation to the status of zinccontaining species in the human body were used as ligands in zinc complexes. Captopril (H 2 Cap) forms the compound [ZnCap] ( 1 ) presumed to be a coordination polymer with O and S coordination. Isoniazid, in the presence of zinc salts, is converted to 1,2‐diisonicotinoyl hydrazide (H 2 Nih) which forms polymeric [Zn(Nih)NH 3 ] ( 2 ) with trigonal‐bipyramidal ZnO 2 N 3 coordination. Nalidixic acid (HNal) and zinc perchlorate yield [Zn(HNal) 2 (H 2 O) 2 ](ClO 4 ) 2 · 2 H 2 O ( 3 ) containing zinc in an octahedral ZnO 6 environment. Mercaptopurine (H 2 Mer), in the presence of ammonia, forms [Zn(Mer)(NH 3 ) 2 ] . H 2 O ( 4 ) which is a coordination polymer containing tetrahedral ZnN 4 units. The structures of [Zn(Nih)NH 3 ], [Zn(HNal) 2 (H 2 O) 2 ](ClO 4 ) 2 . 2 H 2 O, and [Zn(Mer)(NH 3 ) 2 ] . 2 H 2 O were determined diffractometrically.