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Preparation and Characterization of Biologically Active Bismuth(III) Tropolonato Complexes
Author(s) -
Diemer Rolf,
Keppler Bernhard K.,
Dittes Uwe,
Nuber Bernhard,
Seifried Volker,
Opferkuch Wolfgang
Publication year - 1995
Publication title -
chemische berichte
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 0009-2940
DOI - 10.1002/cber.19951280404
Subject(s) - chemistry , bismuth , characterization (materials science) , combinatorial chemistry , stereochemistry , organic chemistry , nanotechnology , materials science
Two new types of bismuth(III) tropolonato complexes, nitratobis(tropolonato)bismuth(III) ( 1d ) and phenylbis(tropolonato)bismuthin ( 1f ), are synthesized and characterized by elemental analysis, 1 H‐NMR, 13 C‐NMR, IR spectroscopy, and conductivity measurements. The structures of 1d and aquabis(4,5‐benzotropolonato)bismuth(III) nitrate ( 6b ) are confirmed by X‐ray structural analyses. Derivatives of tropolone ( 2a ) and their bismuth(III) complexes are synthesized and characterized in the same manner. Eight of these compounds are tested against Helicobacter pylori ( H.p. ) bacteria, which cause chronic gastritis and peptic ulcus. Most of the bismuth compounds show high in vitro activity against H.p.