Pyrazolylborat‐Zinkkomplexe mit Medikament‐Liganden | Zendy

Hartmann Uwe | Zendy; Vahrenkamp Heinrich | Zendy

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Pyrazolylborat‐Zinkkomplexe mit Medikament‐Liganden

Author(s) -

Hartmann Uwe,

Vahrenkamp Heinrich

Publication year - 1994

Publication title -

chemische berichte

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.667

H-Index - 136

eISSN - 1099-0682

pISSN - 0009-2940

DOI - 10.1002/cber.19941271207

Subject(s) - chemistry , carboxylate , denticity , medicinal chemistry , chelation , zinc , ligand (biochemistry) , hydrolysis , tris , stereochemistry , inorganic chemistry , crystal structure , crystallography , organic chemistry , biochemistry , receptor

Pyrazolylborate‐Zinc Complexes with Drugs as Ligands The model complexes for hydrolytic zinc enzymes L 3 Zn‐OH with L 3 a = tris(3‐ tert ‐butyl‐5‐methylpyrazolyl)borate and L 3 b = tris(3‐cumyl‐5‐methylpyrazolyl)borate ( 1a, b ) were tested for their interaction with drugs. With acetazolamide (HAcm) the complex L 3 b Zn‐Acm ( 2b ) is obtained which according to a structure determination contains the Acm ligand chelating by one azole and the sulfonamide nitrogen atoms. Furosemide (HFur) forms the two complexes L 3 Zn‐Fur ( 3 ) which according to their spectra contain the furosemide anion as a monodentate carboxylate ligand. Aspirin (AcSalH) is saponified by both L 3 Zn‐OH complexes yielding L 3 Zn‐Sal ( 4 ). The structure determination of L 3 b Zn‐Sal ( 4b ) has shown the salicylic acid to be bound as a monodentate carboxylate as well.

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