Chiral Organometallic Reagents, XI. Stereoselective Exchange of Diastereotopic Iodine Atoms by Magnesium in 3‐Alkoxy‐1,1‐diiodoalkanes | Zendy

Hoffmann Reinbard W. | Zendy; Kusche Andreas | Zendy

Premium

Chiral Organometallic Reagents, XI. Stereoselective Exchange of Diastereotopic Iodine Atoms by Magnesium in 3‐Alkoxy‐1,1‐diiodoalkanes

Author(s) -

Hoffmann Reinbard W.,

Kusche Andreas

Publication year - 1994

Publication title -

chemische berichte

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.667

H-Index - 136

eISSN - 1099-0682

pISSN - 0009-2940

DOI - 10.1002/cber.19941270721

Subject(s) - chemistry , stereoselectivity , magnesium , alkoxy group , benzaldehyde , iodide , iodine , reagent , halide , medicinal chemistry , group 2 organometallic chemistry , organic chemistry , stereochemistry , catalysis , molecule , alkyl

α‐Iodoalkylmagnesium species were generated by reaction of 3‐oxygenated 1,1‐diiodoalkanes with isopropylmagnesium halides at −78%C. The resulting magnesium carbenoids were found to be configurationally stable at temperatures up to −20%C and were trapped by benzaldehyde or allyl iodide at low temperatures. Stereoselectivity on exchange of the diastereotopic iodine atoms in 3 was found to be low.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research