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Transition Metal‐Catalyzed Annulation Reactions, VII. Palladium‐Catalyzed CH Activation at Methoxy Groups: Regiochemistry of the Domino Coupling Process
Author(s) -
Dyker Gerald
Publication year - 1994
Publication title -
chemische berichte
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 0009-2940
DOI - 10.1002/cber.19941270425
Subject(s) - chemistry , regioselectivity , palladium , catalysis , annulation , domino , reactivity (psychology) , furan , transition metal , medicinal chemistry , cascade reaction , combinatorial chemistry , stereochemistry , organic chemistry , medicine , alternative medicine , pathology
By palladium catalysis substituted ortho‐ iodoanisoles ( 5, 8, 10, 13 ) are transformed either to annulated pyran ( 6 ) or furan derivatives ( 7, 9, 11, 14, 15 ), depending on the reactivity of additional substituents. The regiochemistry of the domino coupling processes is analyzed and a mechanistic rationale developed. Key step is the CH activation at methoxy groups.