Transition Metal‐Catalyzed Annulation Reactions, VII. Palladium‐Catalyzed CH Activation at Methoxy Groups: Regiochemistry of the Domino Coupling Process | Zendy

Dyker Gerald | Zendy

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Transition Metal‐Catalyzed Annulation Reactions, VII. Palladium‐Catalyzed CH Activation at Methoxy Groups: Regiochemistry of the Domino Coupling Process

Author(s) -

Dyker Gerald

Publication year - 1994

Publication title -

chemische berichte

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.667

H-Index - 136

eISSN - 1099-0682

pISSN - 0009-2940

DOI - 10.1002/cber.19941270425

Subject(s) - chemistry , regioselectivity , palladium , catalysis , annulation , domino , reactivity (psychology) , furan , transition metal , medicinal chemistry , cascade reaction , combinatorial chemistry , stereochemistry , organic chemistry , medicine , alternative medicine , pathology

By palladium catalysis substituted ortho‐ iodoanisoles ( 5, 8, 10, 13 ) are transformed either to annulated pyran ( 6 ) or furan derivatives ( 7, 9, 11, 14, 15 ), depending on the reactivity of additional substituents. The regiochemistry of the domino coupling processes is analyzed and a mechanistic rationale developed. Key step is the CH activation at methoxy groups.

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