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Alkylierungsreaktionen mit Alkoholen und Kohlenmonoxid: Eine breit anwendbare Synthese von Thioethern und von Coffein aus Theophyllin
Author(s) -
Bott Kaspar
Publication year - 1993
Publication title -
chemische berichte
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 0009-2940
DOI - 10.1002/cber.19931260828
Subject(s) - chemistry , alkylation , theophylline , carbon monoxide , methanol , potassium , sodium , organic chemistry , medicinal chemistry , catalysis , medicine , endocrinology
Alkylation Reactions by Means of Alkanols and Carbon Monoxide: An Efficient Synthesis of Thioethers and of Caffeine from Theophylline The reaction of sodium or potassium thiolates with alkanols and carbon monoxide provides a versatile route to produce thioethers in excellent yields. By analogy, the potassium salt of theophylline suffers a nearly quantitative conversion to caffeine when heated with methanol under CO pressure. The mechanism of these alkylation reactions is discussed.