Multibridged [3  n  ]Cyclophanes, 1. Synthesis of [3 4 ](1,2,3,5)‐ and ‐(1,2,4,5)Cyclophanes | Zendy

Shinmyozu Teruo | Zendy; Kusumoto Shirou | Zendy; Nomura Sachiyo | Zendy; Kawase Haruo | Zendy; Inazu Takahiko | Zendy

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Multibridged [3 n ]Cyclophanes, 1. Synthesis of [3 4 ](1,2,3,5)‐ and ‐(1,2,4,5)Cyclophanes

Author(s) -

Shinmyozu Teruo,

Kusumoto Shirou,

Nomura Sachiyo,

Kawase Haruo,

Inazu Takahiko

Publication year - 1993

Publication title -

chemische berichte

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.667

H-Index - 136

eISSN - 1099-0682

pISSN - 0009-2940

DOI - 10.1002/cber.19931260810

Subject(s) - cyclophane , chemistry , carbonyl group , group (periodic table) , stereochemistry , medicinal chemistry , crystallography , organic chemistry , crystal structure

The acid‐catalyzed cyclization of a pseudogeminally substituted acetyl group and a chloromethyl group of tri‐bridged cyclophane 7 , followed by reduction of the carbonyl group afforded [3 4 ](1,2,3,5)cyclophane 3 . One‐step TosMIC coupling reaction of tetrabromide 12 and subsequent reduction of the carbonyl groups provided an isomer of 3 , [3 4 ](1,2,4,5)cyclophane 4 .

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