Rate‐Determining Effects in the Formation of Hantzsch 1,4‐Dihydropyridines from  N ‐(1‐Haloalkyl)azinium Halides and Methyl 3‐Amino‐2‐butenoate | Zendy

Eynde JeanJacques Vanden | Zendy; Mayence Annie | Zendy; Maquestiau André | Zendy; Anders Ernst | Zendy

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Rate‐Determining Effects in the Formation of Hantzsch 1,4‐Dihydropyridines from N ‐(1‐Haloalkyl)azinium Halides and Methyl 3‐Amino‐2‐butenoate

Author(s) -

Eynde JeanJacques Vanden,

Mayence Annie,

Maquestiau André,

Anders Ernst

Publication year - 1993

Publication title -

chemische berichte

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.667

H-Index - 136

eISSN - 1099-0682

pISSN - 0009-2940

DOI - 10.1002/cber.19931260527

Subject(s) - chemistry , halide , yield (engineering) , medicinal chemistry , nuclear magnetic resonance spectroscopy , organic chemistry , metallurgy , materials science

N ‐(1‐Haloalkyl)azinium halides react with methyl 3‐amino‐2‐butenoate to yield 4‐substituted dimethyl 1,4‐dihydro‐2,6‐dimethyl‐3,5‐pyridinedicarboxylates. The rates of formation of the latter compounds are monitored by 1 H‐NMR spectroscopy. Mechanistic and practical considerations are discussed.

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