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Makrobicyclische Endorezeptoren: Synthese, Kristallstruktur und Einschluß organischer Gastmoleküle
Author(s) -
Lüer Ingo,
Rissanen Kari,
Vögtle Fritz
Publication year - 1992
Publication title -
chemische berichte
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 0009-2940
DOI - 10.1002/cber.19921250814
Subject(s) - chemistry , dichloromethane , crystal structure , molecule , ligand (biochemistry) , stereochemistry , methanol , crystallography , cyclophane , polymer chemistry , medicinal chemistry , organic chemistry , receptor , solvent , biochemistry
Macrobicyclic Endoreceptors: Synthesis, Crystal Structure, and Inclusion of Organic Guests The macrobicyclic ligand 2 is synthesized in a one‐step cyclization procedure. According to an X‐ray structure analysis three dichloromethane guest molecules are included inside the cavity, whereas water and methanol are found outside the cavity. The rigid endo preorganization of the nitrogen donors allows the complexation of three 2,9‐disubstituted 1,10‐phenanthrolines inside the cavity.