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Catalytic Enantioselective Conjugate Addition of Dialkylzinc Compounds to Chalcones
Author(s) -
Bolm Carsten,
Ewald Martina,
Felder Marcel
Publication year - 1992
Publication title -
chemische berichte
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 0009-2940
DOI - 10.1002/cber.19921250530
Subject(s) - chemistry , enantioselective synthesis , conjugate , catalysis , organic chemistry , combinatorial chemistry , mathematical analysis , mathematics
Conjugate addition of diethylzinc to enones is catalyzed by a complex derived from Ni(acac) 2 and C 2 ‐symmetric 2,2′‐bipyridine 3 or chiral pyridines 5–12 . The products are obtained with optical purities up to 89% ee. A strong positive nonlinear relationship between the enantiomeric excess of the ligand and the ee of the product has been observed. The factors which govern catalyst activity and enantioselectivity have been investigated.