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Asymmetrische Katalysen, 77 [1] Neue optisch aktive Pyrazolderivate für die enantioselektive Katalyse
Author(s) -
Brunner Henri,
Scheck Thomas
Publication year - 1992
Publication title -
chemische berichte
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 0009-2940
DOI - 10.1002/cber.19921250325
Subject(s) - chemistry , optically active , pyrazole , enantioselective synthesis , pyridine , camphor , catalysis , hydrazine (antidepressant) , stereochemistry , medicinal chemistry , organic chemistry , chromatography
Asymmetric Catalysis, 77 [1] . – New Optically Active Pyrazole Derivatives for Enantioselective Catalysis Starting from the amines 3–6 and the dipyrazolopyrazinedione 2 , the optically active (pyrazolylmethyl)amines 11–14 have been synthesized. Furthermore, the preparation of the (+)‐camphor‐derived optically active pyrazole 17 is described. Pyrazoles 11–13 and 17 are introduced as chiral building blocks into the 2‐(1‐pyrazolyl)pyridines 30–33 . The optically active compounds 23–25 are formed from 2‐[3(5)‐pyrazolyl]pyridine and 2,6‐bis[3(5‐)pyrazolyl]pyridine, respectively, and (+)‐3‐(bromomethyl)pinane. The pyrazole derivatives 27–29 contain (+)‐(1‐phenylethyl)hydrazine as the optically active component.