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Crystalline, Enantiomerically Pure Aldols from a (‐)‐Ephedrine‐Derived N ‐Acylimidazolidin‐2‐one
Author(s) -
Drewes Siegfried E.,
Malissar Dean G. S.,
Roos Gregory H. P.
Publication year - 1991
Publication title -
chemische berichte
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 0009-2940
DOI - 10.1002/cber.19911241234
Subject(s) - chemistry , ephedrine , stereochemistry , organic chemistry , neuroscience , biology
Reaction of (4R,5S)‐1,5‐dimethyl‐4‐phenyl‐3‐propanoylimidazolidin‐2‐one with aromatic aldehydes leads to aldol products which, after one recrystallisation have d. e. s > 99%. Removal of the chiral auxiliary affords optically pure β‐hydroxy esters.