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Metallkomplexe mit biologisch wichtigen Liganden, LX. Metallkomplexe von 3′‐Azido‐3′‐desoxythymidin (AZT) und 3′‐Isocyan‐3′‐desoxythymidin
Author(s) -
Pill Thomas,
Polborn Kurt,
Kleinschmidt Andrea,
Erfle Volker,
Breu Walter,
Wagner Hildebert,
Beck Wolfgang
Publication year - 1991
Publication title -
chemische berichte
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 0009-2940
DOI - 10.1002/cber.19911240710
Subject(s) - chemistry , deprotonation , stereochemistry , metal , human immunodeficiency virus (hiv) , medicinal chemistry , virology , organic chemistry , ion , biology
Metal Complexes of Biologically Important Ligands, LX. — Metal Complexes of 3′‐Azido‐3′‐deoxythymidine (AZT) and 3′‐Isocyano‐3′‐deoxythymidine Metal complexes of N‐3‐deprotonated 3′‐azido‐3′‐deoxythymidine (AZT — H + ), (AZT — H + )AuPR 3 (R = Me, Et, Ph) ( 2 , 3 , 4 ), trans ‐(AZT — H + ) 2 Pd(NH 3 ) 2 ( 5 ), [( n ‐Bu 3 P)(AZT — H + ) M(μ‐Cl) 2 M(AZT — H + )(n‐Bu 3 P)] (M = Pd, Pt) ( 6 , 7 ), trans ‐(Ph 3 P) 2 Pd(AZT — H + ) 2 ( 8 ), cis ‐(Ph 3 P) 2 Pt(AZT— H + )(Cl) ( 9 ), and complexes of 3′‐isocyano‐3′‐deoxythymidine (L), (Et 3 P)(L)‐ PdCl, ( 11 ),( 12 ), ( n ‐Bu 3 P)(L)PtCl 2 ( 13 ), [(Ph 3P ) 2 (L)PtCl](BF 4 ) ( 14 ), (η 5 ‐C 5 Me 5 )(L)RhCl 2 ( 15 ), and (η 5 ‐C 5 Me 5 )(L)IrCl 2 ( 16 ) have been prepared and characterized by IR and NMR spectra, 2 by X‐ray crystallography. 2 , 4 , and 9 show an anti‐HIV activity very similar to AZT; 2 exhibits antiinflammatory activity.