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Chiral Organometallic Reagents, III. On the Configurational Stability of α‐Bromoalkyllithium Compounds
Author(s) -
Hoffmann Reinhard W.,
Bewersdorf Martin
Publication year - 1991
Publication title -
chemische berichte
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 0009-2940
DOI - 10.1002/cber.19911240545
Subject(s) - chemistry , lithium (medication) , reagent , bromine , group 2 organometallic chemistry , organometallic chemistry , medicinal chemistry , enantioselective synthesis , organic chemistry , stereochemistry , catalysis , molecule , medicine , endocrinology
Abstract The carbenoids 2 undergo at ‐110°C a bromine/lithium exchange reaction with 1,1‐dibromo alkanes. This leads to partial equilibration of the carbenoids 2 during their generation from the 1,1‐dibromo compound 1 . In the absence of the precursor 1 , the carbenoids 2 have been found to be configurationally stable at ‐110°C.