Synthese mittlerer und großer Ringe, XXVII. Chromatographische Enantiomerentrennung von 3,6‐Heptanophthalid – ein Beitrag zur Frage der absoluten Konfiguration von [ n ]Paracyclophancarbonsäuren

Synthesis of Medium and Large Rings, XXVII 1 . ‐ Chromatographic Separation of the Enantiomeric 3.6‐Heptanophthalides. ‐ A Contribution to the Problem of the Absolute Configuration of [nJ Paracyclophanecarboxylic Acids The partial chromatographic separation of the racemic title compound 1 (ee = 40%) was achieved on triacetylcellulose with ethanol using a recycling technique. Comparison of the CD spectra of (+) 22 365 ‐ 1 with (+) 22 365 ‐ 2 leads to the absolute configuration ( P ) for both compounds. This assignment is of interest in view of earlier configurational assignments for [ n ]paracyclophanecarboxylic acids.