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Synthesis of New Zwitterionic Pyridazino‐ as ‐triazines
Author(s) -
JuhászRiedl Zsuzsanna,
Hajós György,
G´csBaitz Eszter,
Kollenz Gert,
Messmer András
Publication year - 1990
Publication title -
chemische berichte
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 0009-2940
DOI - 10.1002/cber.19901230635
Subject(s) - chemistry , methylhydrazine , triazine , ring (chemistry) , hydrazine (antidepressant) , derivative (finance) , medicinal chemistry , hydrazone , stereochemistry , salt (chemistry) , combinatorial chemistry , organic chemistry , chromatography , financial economics , economics , phenylhydrazine
Reaction of the furo[2,3‐e]pyrido[l,2‐ b ]‐ as ‐triazinium salt 1 with methyl hydrazine gave the zwitterionic 1‐substituted pyrido‐pyridazino‐ as ‐triazine 4 . The neutral 2‐substituted isomer 6 was formed when 1 was treated with 1‐formyl‐1‐methylhydrazine. Reaction of 1 with 1‐acyl‐2‐methylhydrazine gave rise to 1,3,4‐trisubstituted zwitterionic derivatives of the same ring system. Efforts to synthesize aryl‐substituted zwitterions led to simultaneous formation of the desired compound 12 and of a new ring transformation product, the pyrazolopyrido‐ as ‐triazine derivative 15 .