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Neue Synthesen Trifluormethyl‐substituierter Heterocyclen
Author(s) -
Rabe Gerd,
Sundermeyer Jörg,
Roesky Herbert W.,
Schmidt HansGeorg,
Noltemeyer Mathias
Publication year - 1990
Publication title -
chemische berichte
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 0009-2940
DOI - 10.1002/cber.19901230407
Subject(s) - chemistry , thiourea , hydrazide , derivative (finance) , crystal structure , molecule , medicinal chemistry , bicyclic molecule , stereochemistry , organic chemistry , financial economics , economics
New Syntheses of Trifluoromethyl‐Substituted Heterocycles Dimeric hexafluorothioacetone (HFTA) ( 1 ) reacts with thiourea or phenylthiourea to give 1,2,4‐dithiazolines 2a and 2b . Similarly, 1,2,4‐thiaselenazoline 3 is obtained from the reaction of 1 with selenourea. Reaction of 1 with oxamic hydrazide or thiosemicarbazide leads to acyclic molecules 4 and 5 . Besides 5 , the cyclic isomer 6 is also observed in solution. The N ‐trifluoroacetyl derivative 6a is obtained from the reaction of 5 with trifluoracetic anhydride. The structures of 2b, 3, 5 , and 6a have been determined by single‐crystal X‐ray crystallography.