Neue Synthesen Trifluormethyl‐substituierter Heterocyclen | Zendy

Rabe Gerd | Zendy; Sundermeyer Jörg | Zendy; Roesky Herbert W. | Zendy; Schmidt HansGeorg | Zendy; Noltemeyer Mathias | Zendy

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Neue Synthesen Trifluormethyl‐substituierter Heterocyclen

Author(s) -

Rabe Gerd,

Sundermeyer Jörg,

Roesky Herbert W.,

Schmidt HansGeorg,

Noltemeyer Mathias

Publication year - 1990

Publication title -

chemische berichte

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.667

H-Index - 136

eISSN - 1099-0682

pISSN - 0009-2940

DOI - 10.1002/cber.19901230407

Subject(s) - chemistry , thiourea , hydrazide , derivative (finance) , crystal structure , molecule , medicinal chemistry , bicyclic molecule , stereochemistry , organic chemistry , financial economics , economics

New Syntheses of Trifluoromethyl‐Substituted Heterocycles Dimeric hexafluorothioacetone (HFTA) ( 1 ) reacts with thiourea or phenylthiourea to give 1,2,4‐dithiazolines 2a and 2b . Similarly, 1,2,4‐thiaselenazoline 3 is obtained from the reaction of 1 with selenourea. Reaction of 1 with oxamic hydrazide or thiosemicarbazide leads to acyclic molecules 4 and 5 . Besides 5 , the cyclic isomer 6 is also observed in solution. The N ‐trifluoroacetyl derivative 6a is obtained from the reaction of 5 with trifluoracetic anhydride. The structures of 2b, 3, 5 , and 6a have been determined by single‐crystal X‐ray crystallography.

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