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Premium Neue Synthesen Trifluormethyl‐substituierter Heterocyclen
Rabe Gerd,
Sundermeyer Jörg,
Roesky Herbert W.,
Schmidt HansGeorg,
Noltemeyer Mathias
Publication year1990
Publication title
chemische berichte
Resource typeJournals
PublisherWILEY‐VCH Verlag
New Syntheses of Trifluoromethyl‐Substituted Heterocycles Dimeric hexafluorothioacetone (HFTA) ( 1 ) reacts with thiourea or phenylthiourea to give 1,2,4‐dithiazolines 2a and 2b . Similarly, 1,2,4‐thiaselenazoline 3 is obtained from the reaction of 1 with selenourea. Reaction of 1 with oxamic hydrazide or thiosemicarbazide leads to acyclic molecules 4 and 5 . Besides 5 , the cyclic isomer 6 is also observed in solution. The N ‐trifluoroacetyl derivative 6a is obtained from the reaction of 5 with trifluoracetic anhydride. The structures of 2b, 3, 5 , and 6a have been determined by single‐crystal X‐ray crystallography.
Subject(s)bicyclic molecule , chemistry , crystal structure , derivative (finance) , economics , financial economics , hydrazide , medicinal chemistry , molecule , organic chemistry , stereochemistry , thiourea
SCImago Journal Rank0.667

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