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Synthese von 5,5‐disubstituierten 2,5‐Dihydro‐4 H ‐isoindol‐4‐onen
Author(s) -
Spreitzer Helmut,
Mustafa Stefan
Publication year - 1990
Publication title -
chemische berichte
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 0009-2940
DOI - 10.1002/cber.19901230231
Subject(s) - chemistry , medicinal chemistry
Syntheses of 5.5‐Disubstituted 2.5‐Dihydro‐4 H ‐isoindol‐4‐ones Tosylmethyl isocyanide attacks 6,6‐disubstituted cyclohexadienones selectively in position 3 to furnish 4 H ‐isoindol‐4‐one derivatives 4. This is caused by charge distribution, characteristic of cyclohexadienones, and by sterical reasons.