Erschöpfende α‐Alkylierung von Fünfring‐Ketonen mit Natriumhydrid und Dimethylsulfat oder Ethyliodid | Zendy

Knorr Rudolf | Zendy; Mehlstäubl Johann | Zendy; Böhrer Petra | Zendy

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Erschöpfende α‐Alkylierung von Fünfring‐Ketonen mit Natriumhydrid und Dimethylsulfat oder Ethyliodid

Author(s) -

Knorr Rudolf,

Mehlstäubl Johann,

Böhrer Petra

Publication year - 1989

Publication title -

chemische berichte

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.667

H-Index - 136

eISSN - 1099-0682

pISSN - 0009-2940

DOI - 10.1002/cber.19891220927

Subject(s) - chemistry , sodium hydride , cyclopentanone , ketone , alkylation , hydride , methyl iodide , iodide , ethyl iodide , medicinal chemistry , sodium iodide , dimethyl sulfate , organic chemistry , catalysis , hydrogen

Exhaustive α‐Alkylation of Five‐Membered Ring Ketones by Sodium Hydride and Dimethyl Sulfate or Ehtyl Iodide C α ‐Permethylation may be carried out by addition of a basesensitive ketone like cyclopentanone to the inexpensive and stable mixture of sodium hydride and dimethyl sulfate. Exhaustive C α ‐ethylation is exemplified with sodium hydride by simultaneous introduction of ketone 4 and ethyl iodide. The 13 C‐NMR absorptions of 1,3‐alkylated 2‐indanones 3 – 5 are assigned and some of the CH coupling constants reported.

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