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Direct aminolysis of nonactivated and thermally unstable esters at high pressure
Author(s) -
Matsumoto Kiyoshi,
Hashimoto Shiro,
Uchida Takane,
Okamoto Tadashi
Publication year - 1989
Publication title -
chemische berichte
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 0009-2940
DOI - 10.1002/cber.19891220720
Subject(s) - aminolysis , chemistry , alkyl , scope (computer science) , organic chemistry , catalysis , computer science , programming language
The preparation of the amides 3 from a wide variety of nonactivated esters 1 and secondary amines 2 has been achieved at 8 kbar and around 45°C; scope and limitations are discussed. The method was also successfully applied for the aminolysis of alkyl 2‐arylsulfinylacetates 7 that are relatively sensitive to heat.