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( S , S )‐1,3‐Bis[(2‐methoxyethoxy)methoxy]‐1,3‐diphenylacetone – A New Chiral Ketone with C 2 Symmetry
Author(s) -
Braun Manfred,
Moritz Jörg
Publication year - 1989
Publication title -
chemische berichte
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 0009-2940
DOI - 10.1002/cber.19891220632
Subject(s) - chemistry , dilithium , ketone , benzaldehyde , organic chemistry , medicinal chemistry , stereochemistry , catalysis , ion , deprotonation
Starting with carbinol 3 [easily accessible from ethyl ( S )‐lactate], the synthesis of enantiomerically pure, C 2 ‐symmetric ketone 8 is achieved; the key step involves the diastereoselective addition of dilithium compound 4 to benzaldehyde.