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Concerning the Synthesis of [1.1.1]Propellane
Author(s) -
Belzner Johannes,
Bunz Uwe,
Semmler Klaus,
Szeimies Günter,
Opitz Klaus,
Schlüter ArnulfDieter
Publication year - 1989
Publication title -
chemische berichte
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 0009-2940
DOI - 10.1002/cber.19891220233
Subject(s) - propellane , chemistry , methyllithium , cyclopropane , yield (engineering) , decane , ether , cyclopentane , bicyclic molecule , medicinal chemistry , organic chemistry , ring (chemistry) , materials science , metallurgy
The reaction of 1,1‐dibromo‐2,2‐bis(chloromethyl)cyclopropane ( 2 ) with methyllithium in ether led to a solution of [1.1.1]‐propellane ( 1 ) in a yield of 70%. 1 could also be prepared free of solvent by reaction of 2 with lithium powder in triglyme/ n ‐decane at 73°C.
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