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Synthese und Struktur des Zink( l ‐aspartat)chlorids, Zn( L ‐AspH)Cl
Author(s) -
Schmidbaur Hubert,
Bach Ina,
Riede Jürgen,
Müller Gerhard,
Helbig Joachim,
Hopf Günther
Publication year - 1987
Publication title -
chemische berichte
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 0009-2940
DOI - 10.1002/cber.19871200531
Subject(s) - chemistry , zinc , carboxylate , medicinal chemistry , monobasic acid , inorganic chemistry , chloride , aqueous solution , manganese , magnesium , stereochemistry , polymer chemistry , organic chemistry
The reaction of ZnO or ZnCO 3 with L ‐aspartic acid yields zinc di( L ‐aspartate), wherein aspartic acid ( L ‐AspH 2 ) functions as a monobasic acid: Zn( L ‐AspH) 2 . This precursor reacts with one equivalent of ZnCl 2 in aqueous solution at pH=4.25 to give the title compound Zn( L ‐AspH)Cl, which contains no water of crystallisation (solubility: 12.8% [w/w] at 22°C). The X‐ray structure analysis shows the zinc atoms to be tetrahedrally surrounded by a chloride ion and three oxygen atoms of carboxylate groups originating from three different L ‐AspH anions. This constitution is fundamentally different from that of the magnesium analogue, but also of the corresponding halide‐free aspartates and glutamates of zinc and cadmium. The results may be of some significance for pharmacological cooperativity phenomena (chloride/aspartate) in metal complexation.