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Bis(1,2‐dimethyl‐3‐indolizinyl)methane: Structural Studies of a Two‐Bladed Molecular Propeller
Author(s) -
Ceder Olof,
Sharif Mohammed Rashid,
Andersen Leif
Publication year - 1987
Publication title -
chemische berichte
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 0009-2940
DOI - 10.1002/cber.19871200216
Subject(s) - chemistry , propeller , methylene , methane , indolizine , molecule , crystal (programming language) , conjugate , crystal structure , crystallography , stereochemistry , medicinal chemistry , organic chemistry , mathematical analysis , mathematics , marine engineering , computer science , engineering , programming language
An X‐ray structural investigation on bis(1,2‐dimethyl‐3‐indolizinyl)methane ( 1 ) reveals that it occupies a two‐bladed propeller conformation with an anti ‐relation between the central methylene protons and the four methyl groups. In the crystal, the molecule lacks a C 2 axis and it is asymmetric rather than helical. Since the two indolizinyl rings carry no substituents which can conjugate with their π systems the structural results supply, for the first time, accurate information about the geometry of the important heterocycle indolizine.