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Titanium‐Mediated Stereoselective Knoevenagel Condensation of Ethyl (Diethoxyphosphoryl)acetate with Aldehydes
Author(s) -
Reetz Manfred T.,
Peter Roland,
Itzstein Mark Von
Publication year - 1987
Publication title -
chemische berichte
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 0009-2940
DOI - 10.1002/cber.19871200123
Subject(s) - chemistry , knoevenagel condensation , reagent , stereoselectivity , organic chemistry , condensation , titanium , sodium salt , condensation reaction , ethyl cyanoacetate , medicinal chemistry , catalysis , malononitrile , inorganic chemistry , physics , thermodynamics
The titanation of the sodium salt of ethyl (diethoxyphosphoryl)‐acetate ( 1 ) results in a reagent which undergoes a stereoselctive Knoevenagel condensation with aldehydes to form the corresponding trisubstituted olefins 3 having the Z‐configuration.
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