Enantioselektive katalytische Hydrierung von α‐(Acetylamino)‐zimtsäure mit einem Rhodium‐Phosphankomplex in wäßriger Lösung | Zendy

Nagel Ulrich | Zendy; Kinzel Elke | Zendy

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Enantioselektive katalytische Hydrierung von α‐(Acetylamino)‐zimtsäure mit einem Rhodium‐Phosphankomplex in wäßriger Lösung

Author(s) -

Nagel Ulrich,

Kinzel Elke

Publication year - 1986

Publication title -

chemische berichte

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.667

H-Index - 136

eISSN - 1099-0682

pISSN - 0009-2940

DOI - 10.1002/cber.19861190525

Subject(s) - chemistry , rhodium , aqueous solution , catalysis , tetrafluoroborate , medicinal chemistry , cyclooctadiene , cinnamic acid , enantioselective synthesis , organic chemistry , polymer chemistry , ionic liquid

Enantioselective Catalytic Hydrogenation of α‐(Acetylamino)cinnamic Acid with a Rhodium Phosphane Complex in Aqueous Solution The synthesis of [(3 R ,4 R )‐3,4‐bis(diphenylphosphino)‐1,1‐dimethylpyrrolidinium‐ P , P ′](1,5‐cyclooctadiene)rhodium bis(tetrafluoroborate) ( 5 ) is described. With this water‐soluble catalyst the sodium salt 6c of α‐(Acetylamino)cinnamic acid ( 6a ) is hydrogenated in aqueous solution to give ( S )‐ N ‐acetylphenylalanine with 90% ee.

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