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Enantioselektive katalytische Hydrierung von α‐(Acetylamino)‐zimtsäure mit einem Rhodium‐Phosphankomplex in wäßriger Lösung
Author(s) -
Nagel Ulrich,
Kinzel Elke
Publication year - 1986
Publication title -
chemische berichte
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 0009-2940
DOI - 10.1002/cber.19861190525
Subject(s) - chemistry , rhodium , aqueous solution , catalysis , tetrafluoroborate , medicinal chemistry , cyclooctadiene , cinnamic acid , enantioselective synthesis , organic chemistry , polymer chemistry , ionic liquid
Enantioselective Catalytic Hydrogenation of α‐(Acetylamino)cinnamic Acid with a Rhodium Phosphane Complex in Aqueous Solution The synthesis of [(3 R ,4 R )‐3,4‐bis(diphenylphosphino)‐1,1‐dimethylpyrrolidinium‐ P , P ′](1,5‐cyclooctadiene)rhodium bis(tetrafluoroborate) ( 5 ) is described. With this water‐soluble catalyst the sodium salt 6c of α‐(Acetylamino)cinnamic acid ( 6a ) is hydrogenated in aqueous solution to give ( S )‐ N ‐acetylphenylalanine with 90% ee.